Enteric alpha‐synuclein expression is increased in Parkinson's disease but not Alzheimer's disease
Identifieur interne : 001004 ( Main/Exploration ); précédent : 001003; suivant : 001005Enteric alpha‐synuclein expression is increased in Parkinson's disease but not Alzheimer's disease
Auteurs : Andrea Gold [Canada] ; Zorbey T. Turkalp [Canada] ; David G. Munoz [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2013-02.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Alzheimer Disease (metabolism), Alzheimer Disease (pathology), Autopsy, Brain (pathology), Enteric Nervous System (metabolism), Enteric Nervous System (pathology), Female, Humans, Immunohistochemistry, Lewy Bodies (pathology), Male, Middle Aged, Myenteric Plexus (pathology), Parkinson Disease (metabolism), Parkinson Disease (pathology), Submucous Plexus (pathology), Young Adult, alpha-Synuclein (biosynthesis).
- MESH :
- chemical , biosynthesis : alpha-Synuclein.
- metabolism : Alzheimer Disease, Enteric Nervous System, Parkinson Disease.
- pathology : Alzheimer Disease, Brain, Enteric Nervous System, Lewy Bodies, Myenteric Plexus, Parkinson Disease, Submucous Plexus.
- Adult, Aged, Aged, 80 and over, Autopsy, Female, Humans, Immunohistochemistry, Male, Middle Aged, Young Adult.
Abstract
Alpha‐synuclein (α‐Syn) is immunohistochemically detectable in enteric neurons in some subjects. We determined its age distribution in the general autopsy population and in an age‐matched subset investigated differences with Parkinson's (PD) and Alzheimer's diseases (AD).
Url:
DOI: 10.1002/mds.25298
Affiliations:
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Turkalp</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine, St. Michael's Hospital, University of Toronto & Li Ka Shing Knowledge Institute, Ontario, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G." last="Munoz">David G. Munoz</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine, St. Michael's Hospital, University of Toronto & Li Ka Shing Knowledge Institute, Ontario, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-02">2013-02</date><biblScope unit="volume">28</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="237">237</biblScope><biblScope unit="page" to="241">241</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">ECB885A980B44E5E53A297F492BEB3B7E6F86B64</idno><idno type="DOI">10.1002/mds.25298</idno><idno type="ArticleID">MDS25298</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Alzheimer Disease (metabolism)</term><term>Alzheimer Disease (pathology)</term><term>Autopsy</term><term>Brain (pathology)</term><term>Enteric Nervous System (metabolism)</term><term>Enteric Nervous System (pathology)</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Lewy Bodies (pathology)</term><term>Male</term><term>Middle Aged</term><term>Myenteric Plexus (pathology)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Submucous Plexus (pathology)</term><term>Young Adult</term><term>alpha-Synuclein (biosynthesis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term><term>Enteric Nervous System</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term><term>Brain</term><term>Enteric Nervous System</term><term>Lewy Bodies</term><term>Myenteric Plexus</term><term>Parkinson Disease</term><term>Submucous Plexus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Autopsy</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Alpha‐synuclein (α‐Syn) is immunohistochemically detectable in enteric neurons in some subjects. We determined its age distribution in the general autopsy population and in an age‐matched subset investigated differences with Parkinson's (PD) and Alzheimer's diseases (AD).</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Gold, Andrea" sort="Gold, Andrea" uniqKey="Gold A" first="Andrea" last="Gold">Andrea Gold</name></noRegion><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G." last="Munoz">David G. Munoz</name><name sortKey="Turkalp, Zorbey T" sort="Turkalp, Zorbey T" uniqKey="Turkalp Z" first="Zorbey T." last="Turkalp">Zorbey T. Turkalp</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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